唐剑 博士，副教授，硕士生导师，南京大学有机化学博士。主要的研究领域包括不限于：多肽选择性修饰；过渡金属催化C-H活化；功能导向小分子合成；可见光催化等。近年来，在Nature Communications，Chemical Science，Organic Letters，Chemical Communications，The Journal of Organic Chemistry等国际知名期刊发表研究论文20余篇，主持中国博士后基金面上项目，山东省自然科学基金青年项目，动漫之家 科研基金，配位化学国家重点实验室开放课题及多项横向课题。主讲《有机化学》《有机合成化学》《有机化学实验》等课程。

联系方式

[email protected]；[email protected]

QQ：604412479

实验室：实验中心B304，办公地点：实验中心B301

代表性科研论文

1. Jian Tang,* Qinyu Lu, Han Chu, Hongrui Man, Kun Liu, Caiyue Yuan. Copper-Catalyzed Selective N-Sulfenylation of Tryptophan-Containing Peptides. Organic Letters 2025, 27, 14107.

2. Jian Tang,* Yi Sun, Qinyu Lu, Fengjie Lu, Shina Yan, Yan Liu. Palladium-Catalyzed Late-Stage Maleimidation of Phenylalanine-Containing Peptides. Organic Letters 2025 27, 9542.

3. Jian Tang, * Qinyu Lu, Fengjie Lu, Yi Sun, Yuqi Pan, Weishuai Qu. Methionine-facilitated chalcogenation of peptides through palladium-catalyzed β-C(sp³)-H activation. Chemical Communications 2025, 61, 16604.

4. Ziping Cao,* Yao Ji, Xuteng Lang, Jiarui Li, Jia‘ao Han, Jian Tang, Ensheng Zhang, Yuanchun He, Xiaoxiang Zhang, and Xin Meng.* Structural Engineering of Chiral Naphthalene-Based Sandwich Emitters: Circularly Polarized Luminescence and Modulation of Charge-Transfer Mechanisms. ACS Applied Materials & Interfaces 2025 17, 53865.

5. Yao Ji, Xin Meng, Jia’ao Han, Yanchen Liu, Jian Tang, Yuanchun He, Ensheng Zhang, Xiaoxiang Zhang, Ziping Cao*. New J. Chem., 2025,49, 8428.

6. Jian Tang,* Fengjie Lu, Xinyi Zhang, Zhenqi Gao, Shuo Gong, Ensheng Zhang, Backbone-Enabled and Ester Groups Switched δ‑C(sp²)-H Amination/Fluorination: Cyclic Dipeptides Synthesis. Organic Letters 2024, 26, 5130.

7. Fengjie Lu, Yujie Geng, Huihui Wang, Ya-ning Liu, Ensheng Zhang,* Liyun Yang,* Jian Tang,* Late-Stage Modification of Peptides with Maleimides through Palladium-Catalyzed β‑C(sp³)-H Alkylation. Organic Letters 2024, 26, 8786.

8. Fengjie Lu, Xinyi Zhang, Yujie Geng, Huihui Wang, Jian Tang.* Methionine-enabled peptide modification through late-stage Pd-catalyzed β-C(sp³)-H olefination/cyclization. Chemical Communications 2024, 60, 7942.

9. Fengjie Lu, Yi Sun, Ya-ning Liu, Yujie Geng, Ensheng Zhang, Jian Tang.* Backbone-enabled modification of peptides with benzoquinone via palladium-catalyzed δ-C(sp²)-H functionalization. Chemical Communications 2024, 60, 1754.

10. Jian Tang,* Fengjie Lu, Yujie Geng, Yanxia Liu, Ensheng Zhang，Site-Selective Modification of Peptides via Late-Stage Pd-Catalyzed Tandem Reaction of Phenylalanine with Benzoquinone，Organic Letters 2023, 25, 5378.

11. Jian Tang,* Fengjie Lu, Xinyi Zhang, Yiming Su, Ensheng Zhang, Zhiyu Yang, Copper-Catalyzed Chemodivergent Synthesis of Oxazoles and Imidazolidones by Selective C−O/C−N Cyclization. The Journal of Organic Chemistry 2023, 88, 9835.

12. Jian Tang,* Fengjie Lu, Yi Sun, Guodong Zhang, Ensheng Zhang and Yuan-Ye Jiang, Late-Stage Diversification of Peptides via Pd-Catalyzed Site-Selective δ-C(sp²)-H Fluorination and Amination. The Journal of Organic Chemistry 2023, 88, 14165.

13. Jian Tang,* Fengjie Lu, Yi Sun, Zhiyu Yang, Ensheng Zhang, Jingwei Lv, Relay Copper-Catalyzed to Synthesis Imidazo[1,5-a]pyridine Scaffolds from Phenylalanine and Halohydrocarbon，The Journal of Organic Chemistry 2023, 88, 17499.

14. Qingqing Bai, Jian Tang, Huan Wang.* Functionalization of Sulfonamide-Containing Peptides through Late-Stage Palladium-Catalyzed C(sp³)-H Arylation. Organic Letters 2019, 21, 5858

15. Jian Tang, Hongfei Chen, Yadong He, Wangjian Sheng, Qingqing Bai,Huan Wang.* Peptide-guided functionalization and macrocyclization of bioactive peptidosulfonamides by Pd(II)-catalyzed late-stage C-H activation. Nature Communications 2018, 9, 3383.

16. Jian Tang, Jingxia Lu, Qunfeng Luo, Huan Wang.* Discovery and biosynthesis of thioviridamide-like compounds. Chinese Chemical. Letters 2018, 29, 1022.

17. Jie Wu, Jian Tang, Hongfei Chen, Yadong He, Hequan Yao* and Huan Wang.* Recent developments in peptide macrocyclization. Tetrahrdron Lett. 2018, 59, 325-333.

18. Jian Tang, Yadong He, Hongfei Chen, Wangjian Sheng, Huan Wang.* Synthesis of bioactive and stabilized cyclic peptides by macrocyclization using C(sp³)-H activation. Chemical Science 2017, 8, 4565.

19. Jian Tang, Günter Grampp, Yun Liu, Bing-Xiang Wang, Fei-Fei Tao, Li-Jun Wang, Xue-Zheng Liang, Hui-Quan Xiao, Yong-Miao Shen.* Visible Light Mediated Cyclization of Tertiary Anilines with Maleimides Using Nickel(II) Oxide Surface-Modified Titanium Dioxide Catalyst. The Journal of Organic Chemistry 2015, 80, 2724.

20. Jian Tang, Xuezheng Liang.* Highly efficient procedure for biodiesel synthesis using polypyrrole functionalized by sulfonic acid. Kinetics and Catalysis 2015, 56, 323.

21. Jian Tang, Jia-Jun Yue, Fei-Fei Tao, Guenter Grampp, Bing-Xiang Wang, Fang Li, Xue-Zheng Liang, Yong-Miao Shen,* Jian-Hua Xu. A Three-Component Reaction by Photoinduced Electron Transfer Mechanism with N-Protected Pyrroles as Neutral Carbon Nucleophiles. The Journal of Organic Chemistry 2014, 79, 16, 7572.

22. Jian Tang. Yuliang jiang. Bingxiang Wang. Yongmiao Shen.* Synthesis and Antimicrobial Activities of Oxazepine and Oxazocine Derivatives. Zeitschrift für Naturforschung C. 2014, 69, 7.

专利申请

1.环肽化合物及钯催化C-H烷基化构建该环肽化合物的方法, 唐剑; 宿一明; 杨智杰; 杨明璐; 杨丽云, ZL 2022 1 0077154.5

2.一种恶唑衍生物及其合成方法，唐剑， 陆丰杰，张馨怡，于子辰，张国栋，杨志宇， 202211383966.9

3.一种4-氟-吲哚啉化合物及其制备方法与应用，唐剑，孙毅，刘雅宁，陆丰杰，张国栋，张恩生，CN 117229350 A

4.一种 DKPs 化合物及其构建方法和应用，唐剑，鹿钦宇，耿瑜婕，陆丰杰，孙毅， 202410475867.6

学生培养

2022级硕士陆丰杰获“研究生国家奖学金”“圣地英才奖”

2022级硕士生陆丰杰到南京大学攻读博士学位

2025届本科生耿瑜婕获动漫之家 “优秀学士论文”